Lechleri Croton (Croton lechleri)
Lechleri Croton (Croton lechleri) is the representative plant of the family Euphorbiaceae, comprising about 1200 species, native to the Amazon basin. “Dragon’s blood” is the name of a wood extract of Croton lechleri — dark krasnoshchel resin. “Dragon’s blood” used by the Indians of Central and South America in folk medicine for many centuries and is considered one of the most potent natural medicines on all occasions. In folk medicine it is believed that the resin has antimicrobial, antiviral, antifungal, anti-inflammatory effects that can stop bleeding and accelerate wound healing, stop diarrhea and much more.
New antidiarrheal drug approved for therapy related side effects of antiretroviral therapy. Crofelemer showed efficacy and safety in clinical trials involving 696 receiving antiretroviral therapy for HIV-infected patients, of whom 374 were selected patients with stable (a month or more) symptoms of diarrhea. The median number of daily watery bowel movements was 2.5 times a day. Tests showed that 17.6% of patients taking the 125 mg crofelemer twice a day, reliably and significantly decreased the frequency of diarrhea compared with 8% of patients in the placebo group. Some patients showed persistent antidiarrheal effect lasting up to 20 weeks.
The most frequently observed in clinical trials adverse events in patients receiving crofelemer included: infections of the upper respiratory tract, bronchitis, cough, meteorism and increased levels of bilirubin.
Crofelemer as any antidiarrheal medication, carries risks of worsening the patient’s condition in cases where the cause of the diarrhea is not side effects medicines and not diagnosed with an infectious agent.
Unfortunately, in the foreseeable future registration of the drug Fulyzaq, for a number of reasons it seems unlikely.